# Top bar: Info and actions

The top bar contains information about the current user, selected variant, as well as action buttons. The figure below shows the top bar in the ANALYSIS workflow, where there are three sections, for global and variant-specific information/actions, respectively:

The view in VARIANTS workflow is almost the same but contains no sample-specific information, and has an extra button to show analyses containing the variant.


If available, the RefSeq transcript and version used in the HGVSc variant name in the top bar (NM_175629.2 in the example above) matches what is specified in the gene panel. However:

  • If the same transcript version is not found, the newest version available in the annotation is used.
  • If no matching transcript reference is found (regardless of version), all available transcripts are shown.

# Action buttons

Various action buttons are available in the top bar, divided by Global actions (middle section) and Variant actions (specific for the chosen variant).

# Global

Button Explanation More information
INFO / CLASSIFICATION / REPORT Switch between pages for sample information, classification of variants and reporting
SNV / CNV Switch between mode for SNVs and CNVs. Note: CNV mode is currently disabled by default, meaning these buttons will not be visible under normal circumstances.
GENE PANEL INFO Show information about the gene panel used in the current analysis. Gene panel info
WORK LOG System and user messages related to current analysis/interpretation. The number of user added messages is shown in parentheses. Work log
Start, save changes and finish an analysis or interpretation. Start; Save/Finish

# Variant

Button Explanation More information
COPY VARIANT TO ALAMUT Copy currently selected variant to clipboard in Alamut format. Links
SHOW ANALYSES In VARIANTS workflow only; allows you to view any existing analyses containing the variant. Show analyses ...
ADD ACMG Add an ACMG criterion manually. Classification section
ADD ATTACHMENT Add an attachment (picture or file) to a comment field. Comments and attachments
COLLAPSE ALL Collapse all evidence sections. Use collapsing for overview ...

# Gene information

Clicking on the gene name in the top bar gives you extended information about the particular gene:

Header Explanation More information
LINKS Click to go to corresponding gene information pages from external resources.
INHERITANCE Inheritance mode, specified in the gene panel. Gene panels
PHENOTYPES Associated phenotypes, specified in the gene panel. Gene panels
TRANSCRIPTS Shows the default transcript(s) used in the gene panel. Gene panels
BS1/BA1 CUTOFF Frequency thresholds for automatic suggestions of the corresponding ACMG-AMP criteria (divided by external and internal database). User group-specific ACMG rules
GENE COMMENTS User-added gene information. (see below)

The GENE COMMENTS field is editable; click the EDIT button and UPDATE when you have made changes. This can be done even if the analysis itself has not been started. If a comment has been added, an INFO tag is shown next to the gene name.


In the current iteration, no collision warnings will be shown if another user is editing the information at the same time, and there is a risk for overwriting each other's work if this happens.

# Analysis history

When analyses with an existing, finished workflow step is opened and before it is started/reopened, a drop-down with the analysis history (with all previous workflow steps) is shown in the top bar (right). To switch between views of current data or any previous interpretation rounds, use the drop-down:

When you select a a previous workflow step, all variants are shown with the variant interpretations, classifications and annotation available at the time that step was finished. As this may differ from the current state (especially if the interpretation was done a long time ago), ELLA shows a warning about historical data, as in the above example.

By default, non-finalized analyses (e.g. in a review step) are shown with current data selected, whereas finalized analyses are shown with the last finished workflow step selected.

Note that if you click REOPEN/START ..., the drop-down disappears and the annotation and variant interpretations shown are always equal to the most current state, irrespective of what was selected in the drop-down.


This history view is specific to analyses performed in ANALYSES mode and does not include history of independent variant interpretations performed in VARIANTS mode (if any). See also variant-specific classification histories.

# User profile and history

By clicking your user name (top right corner), you will get an overview of your profile and interpretation history. Clicking on a variant/sample under YOUR ACTIVITY will open that variant/sample.

This page also includes a LOGOUT button (top right).


Checking the user history will exit any currently active interpretation, so remember to save your work first!

Last Updated: 6/18/2024, 11:26:05 AM